ABSTRACT New simple,  sensitive,  accurate, and  inexpensive  spectrophotometric  technique  has been  developed  for  the  estimation  of Metochloropramide hydrochloride [MCP-HCl] in pure and pharmaceutical preparation.  This technique is based on the diazotization  of a primary amino group of Metochloropramide  hydrochloride  [MCP-HCl] with NaNo2  and HCl followed by coupling  with  p-nitro  aniline  in  alkaline  medium  to  obtain  a  stable  red-colored  water-soluble  azo-dye,  show a  maximum absorption (λmax) at 513. 50nm. Bear,s  low is obeyed in the concentration range of (0.2–25)  µg.ml-1  with molar absorptivity of 2.313×103L.mol-1.cm-1and sandall’s sensitivity  0.0145  µg.mL-2.  The limit  of detection  (LOD) and limit  of quantitative  were 0.182  µg.mL-1and 0.553  µg.mL-1, respectively.  The proposed technique successfully applied to (tablets, syrup,  and injection). Keywords:  Determination, Diazotization reaction, Dosage forms,  Metochlorobromide, Spectrophotometric. International Journal of Drug Delivery  Technology (2020); DOI: 10.25258/ijddt.10.1.11 How to cite this article:  Abd  Alrada  WA, Sulaiman ID. Determination of Metochloropramide Hydrochloride by Spectrophotometric  Method by using Diazotized  p-nitro  aniline  reagent.  International  Journal of Drug Delivery  Technology. 2020;  10(1):68-73.