Abstract

The anti-diabetic drug liraglutide was loaded within LDH nanoparticles using the Fe+3, Al+3, Fe+2and Ni+2 ions, the preparation of LDH was carried out via the titration of 2M of NaOH with trivalent and divalent ions in presence 0.5M HCl, the prepared compounds of liraglutide with LDH were tasted with selective groups of rats.

The compounds were characterized with Fourier transform infra-red (FTIR), X-ray diffraction (XRD), Atomic force microscopy (AFM), Zeta potential and Scanning electron microscopy (SEM).

The animals that injected with weekly dose of the prepared compounds shows the weight reduction comparative with that of the animals injected daily dose of pure liraglutide. 

Keyword; Liraglutide, double layered hydroxide, nanoparticles, antidiabetic drug.

Synthesis and Characterization

Abstract

    The liraglutide, antidiabetic drug, was loaded with layered double hydroxide nanoparticles for selective ions such as Fe+3, Fe+2, Ni+2 and Al+3, the LDH were prepared through the titration method by adding 2M of NaOH to the mixture of trivalent, divalent ions and 0.5M HCl, the drug liraglutide was added to prepared layered. The compounds were characterized by SEM, AFM, FT-IR, XRD and Zeta potential technique.

Key words: liraglutide, LDH, nanoparticales

ABSTRACT
Pelargonium graveolens (P. graveolens), commonly known as rose geranium it is native to the southern parts of Africa.
Phytochemical studies show that this plant is rich in flavonoids, terpenoids, volatile oil, tannins, and glycosides. It has important pharmacological activities including antibacterial, antifungal, and antidiabetic and antioxidant activity. This is a novel study of Pelargonium graveolens cultivated in Iraq. In this study, the preliminary tests indicate the presence of active constituents in the leaves including terpenoids, flavonoids, alkaloids and tannin. This study also involved studying the antibacterial activity of Pelargonium graveolens hexane and ethanol leaves extracts and was performed on gram negative bacteria species (Escherichia coli) and one gram positive bacteria (Staphylococcus aureus). The antibacterial study was performed by ager well diffusion method. The ethanol extract shows good results against examined bacteria while hexane extract shows no antibacterial activity against examined bacteria.
Keywords: Pelargonium graveolens, rose geranium, antibacterial activity, agar well diffusion method.