Coronavirus (COVID-19), is an infectious disease recognized in late December, 2019, in Wuhan city of China, was established as a pandemic by the World Health Organization. Most countries have declared some lockdown to diminish the effects of COVID-19 and terminate the transmission of novel coronavirus. Novel study shows that long-term exposure to air pollution could contribute to higher numbers of COVID-19 fatalities. According to the World Health Organization, 4.6 million individuals die annually from diseases and illnesses directly related to poor air quality. Meteorological conditions may also have a significant role in air pollution–virus interactions. Previous studies have suggested that ambient air pollutants are risk factors for respiratory infection by carrying microorganisms to make pathogens more invasive to humans and affecting the body's immunity to make people more susceptible to pathogens.

Aim of study is to investigate the possible effect of Bosentan as anti-hyperlipidemic agent in mice. The. Thirty-two male albino mice were fed a high cholesterol diet for 28 days to construct hyperlipidemic models. The anti-hyperlipidemic activity Bosentan against hyperlipidemia induced was evaluated in mice. Atorvastatin was used as a standard. Total cholesterol, triglycerides, highdensity
lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were measured. Compared with normal mice, hyperlipidemic mice possessed significantly higher lipid and liver enzymes profile outcomes. After treatment Bosentan, lipid levels and liver enzymatic activities in hyperlipidemic mice significantly decreased. Besides that, Bosentan treated group showed significant improvement in levels of tissue MDA and GPx in hyperlipidemic mice