م.د مهند عبد الامير حسين
  • NHC-Catalyzed Metathesis and Phosphorylation Reactions of Disulfides: Development and Mechanistic Insights
  • Abstract: The development of efficient methods for the
    metathesis and phosphorylation reactions of disulfide
    compounds is of widespread interest due to their important
    synthetic utility in polymer, biological, medicinal and
    agricultural chemistry. Herein, we demonstrate the use of
    N-heterocyclic carbenes (NHCs) as versatile organocatalysts
    to promote these challenging reactions under mild
    conditions. This metal- and oxidant-free protocol is operationally
    simple with very short reaction times. The interplay
    between the nucleophilicity and basicity of NHCs in
    these reactions were also elucidated by NMR studies and
    high-level ab initio calculations.

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